Acacetin Suppresses IL-1<i>β</i>-Induced Expression of Matrix Metalloproteinases in Chondrocytes and Protects against Osteoarthritis in a Mouse Model by Inhibiting NF-<i>κ</i>B Signaling Pathways

<div>Cytotoxicity and MMP inhibitory effect of acacetin in human primary chondrocytes. (a) Chemical structural formula of acacetin. (b) Viability of chondrocytes treated with acacetin (0–200 <i>μ</i>M) for 48 h. (c) Chondrocytes were treated with acacetin (H-acacetin, 6.25 <i>μ</i>M; L-acacetin, 3.125 <i>μ</i>M) and IL-1<i>β</i> (10 ng/mL) for 24 h. 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BioMed Research International

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Figure 2

Figure 2: Acacetin Suppresses IL-1<i>β</i>-Induced Expression of Matrix Metalloproteinases in Chondrocytes and Protects against Osteoarthritis in a Mouse Model by Inhibiting NF-<i>κ</i>B Signaling Pathways 

Figure 2 | Acacetin Suppresses IL-1β-Induced Expression of Matrix Metalloproteinases in Chondrocytes and Protects against Osteoarthritis in a Mouse Model by Inhibiting NF-κB Signaling Pathways 