Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells

<div>ELK3 knockdown inhibits migration of DU145 cells partly by upregulating SERPINE1 via AKT activation. (a) ELK3 knockdown resulted in upregulation of SERPINE1 and activation of AKT in DU145 cells. (b) Silencing SERPINE1 by specific siRNA in ELK3 knockdown DU145 cells modestly rescued the migration ability. (c) Inhibition of AKT with its inhibitor miltefosine (5 <i>μ</i>M) attenuated SERPINE1 expression induced by ELK3 silencing. 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BioMed Research International

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Figure 4

Figure 4: Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells 