Association of Tumor Necrosis Factor Receptor 1 Promoter Gene Polymorphisms (-580 A/G and -609 G/T) and TNFR1 Serum Levels with the Susceptibility to Gastric Precancerous Lesions and Gastric Cancer Related to H. pylori Infection in a Moroccan Population
Table 1
TNFR1 promoter polymorphisms at positions -609 and -580 in patients with gastric lesions and healthy controls.
HC
CG
PL
GC
(%)
(%)
(%)
(%)
TNFR1 -609 G/T genotypes
GG
34 (54.0)
33 (50.8)
27 (54)
27 (67.5)
GT
11 (17.4)
17 (26.1)
15 (30)
9 (22.5)
TT
18 (28.6)
15 (23.1)
8 (16)
4 (10.0)
value
0.47
0.15
0.07
OR, [95% CI], value (TT+GT vs. GG)
1, [0.5-2.1], 0.86
0.9, [0.42-1.9], 0.8
0.5, [0.2-1.3], 0.2
OR, [95% CI], value (GG+GT vs. TT+GT)
0.9, [0.5-1.9], 1
0.8, [0.4-1.7], 0.7
0.5, [0.2-1.2], 0.2
OR, [95% CI], value (GG+GT vs. TT)
0.7, [0.3-1.6], 0.5
0.4, [0.1-1.2], 0.2
0.3, [0.09-0.9], 0.03
TNFR1 -609 G/T alleles
G
79 (62.7)
83 (63.8)
69 (69)
63 (78.7)
T
47 (37.3)
47 (36.2)
31 (31)
17 (21.3)
value
0.85
0.32
0.01
OR, [95% CI], value (T vs. G)
0.9, [0.6-1.6], 0.89
0.7, [0.4-1.3], 0.33
0.4, [0.2-0.8], 0.02
TNFR1 -580 A/G genotypes
AA
45 (71.4)
55 (84.6)
33 (66)
33 (82.5)
AG
16 (25.4)
9 (13.8)
17 (34)
6 (15)
GG
2 (3.2)
1 (1.6)
0 (0)
1 (2.5)
value
0.17
0.42
0.42
OR, [95% CI], value (GA+GG vs. AA)
0.4, [0.2-1.1], 0.08
1.3, [0.6-2.9], 0.54
0.5, [0.2-1.4], 0.24
OR, [95% CI], value (AA+GA vs. GG+GA)
0.5, [0.2-1.2], 0.1
1.1, [0.5-2.5], 0.8
0.6, [0.2-1.6], 0.36
OR, [95% CI], value (AA+GA vs. GG)
0.5, [0.04-5.4], 0.6
0, [0-0], 0.5
0.6 [0.07-8.9], 1
TNFR1 -580 A/G alleles
A
106 (84.1)
119 (93)
83 (83)
72 (90)
G
20 (15.9)
11 (7)
17 (17)
8 (10)
value
0.08
0.82
0.23
OR, [95% CI]; value (G vs. A)
0.5, [0.2-1], 0.08
1.1, [0.5-2.2], 0.85
0.6, [0.2-1.4], 0.29
HC: healthy controls; CG: chronic gastritis; PL: precancerous lesions; GC: gastric cancer. values were calculated using the chi-squared test or Fisher test.
