An Integrated Transcriptomic and Proteomic Analysis Identifies Significant Novel Pathways for Henoch-Schönlein Purpura Nephritis Progression

Table 1

The demographic and clinical characteristics of patients in this study.

	HSP									HSPN (type 1)			HSPN (type 2)			HSPN (type 3)
Pathological type	—	—	—	—	—	—	—	—	—	Ia	Ib	Ib	IIb	IIa	IIb	IIIa	IIIa	IIIb
Patient ID	1	2	3	4	5	6	7	8	9	1	2	3	1	2	3	1	2	3
Sex	1^a	2	2	1	1	2	1	1	2	1	1	2	2	1	1	1	1	2
Man/woman	5/4									6/3
Age	7	15	13	6	13	11	10	7	6	11	10	5	9	10	16	8	9	10
Mean age	9.78									9.78
Arthralgias and/or arthritis^b	1	0	2	0	1	1	0	1	0	1	1	0	2	0	0	1	1	1
Bowel angina and/or gastrointestinal bleeding	2	0	0	0	1	2	0	0	1	1	0	1	1	0	1	1	2	1
Proteinuria/hematuria	0	1	0	0	0	0	1	0	0	2	2	2	3	2	3	3	3	3
IgA (g/l)	2.53	1.67	2.54	1.65	2.18	1.21	1.98	1.94	1.96	1.02	1.19	2.45	1.72	3.35	4.48	2.65	3.00	7.16
Mean IgA	1.96									1.55			3.18			4.27
CRP (mg/l)	1.51	2.58	1.89	0.73	0.79	3.14	1.77	1.98	1.56	1.67	1.87	1.43	6.32	8.38	8.42	11.45	15.05	20.80
Mean CRP	1.77									1.66			7.71			15.77
C3 (g/l)	1.01	0.86	0.79	1.03	0.96	0.86	0.92	1.12	0.72	0.95	1.12	1.08	1.14	1.16	1.12	1.04	1.46	1.16
Mean C3	0.92									1.05			1.14			1.22
C4 (g/l)	0.15	0.22	0.19	0.12	0.22	0.35	0.23	0.21	0.20	0.12	0.27	0.26	0.33	0.19	0.23	0.22	0.26	0.19
Mean C4	0.21									0.22			0.25			0.22

^a1 and 2 denote boy and girl, respectively. ^bJoint: 0 = no symptoms; 1 = pain and/or slight swelling; 2 = pain and/or moderate swelling; 3 = pain and/or severe swelling; GI: 0 = no symptom; 1 = slight pain and/or occult stool blood (OSB) (+); 2 = moderate pain and/or OSB (+2, +3); 3 = severe and/or melena; kidney: 0 = no proteinuria; 1 = proteinuria (+) and/or hematuria (+); 2 = proteinuria (2+, 3+) and/or hematuria (2+, 3+); 3 = proteinuria (>3+) and/or hematuria (>3+).