Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways

Figure 4

The combination of TF and gefitinib synergistically inhibited the expression of Bcl-2 and Mcl-1. (a) PC-9R cells were treated with 17 μM gefitinib alone or combine with 30 μg/ml TF for 24 h. Proteins were extracted and subjected to Western blotting assay to evaluate Bcl-2 and Mcl-1. (b) Quantitative analysis expression of proteins in (a). Data was presented by for three separate experiments. ; .

(a)

(b)