Genomic Analysis Reveals Novel Specific Metastatic Mutations in Chinese Clear Cell Renal Cell Carcinoma

Figure 4

Analysis of differential mutation genes. (a) 101 mutated genes of different frequencies between the metastatic and nonmetastatic groups. (b) The location of identified TOP1 and SNCAIP variants. (c) The distribution of identified VHL, PBRM1, and BAP1 variants in the nonmetastatic (left) and metastatic (right) groups. The grey bar represents the entire protein marked with an amino acid number. The height of the grey line indicates the number of a specific mutation, and the colored circle on the grey line represents the corresponding mutation types. Green: missense; black: truncating; brown: inframe indels; purple: other.

(a)

(b)

(c)