Profiles of PD-1, PD-L1, PD-L2 in Gastric Cancer and Their Relation with Mutation, Immune Infiltration, and Survival

Table 1

Association of mutations with PD-1, PD-L1, and PD-L2 expressions in gastric cancer.

Gene	Mutation	PD-1			PD-L1			PD-L2
		Mean	SD		Mean	SD		Mean	SD
ARID1A	No	0.612	1.164		2.407	23.912		0.508	1.133
ARID1A	Yes	0.673	0.844	0.877	0.646	0.835	0.866	0.567	0.862	0.719
CSMD1	No	0.597	1.176		1.032	5.874		0.458	0.987
CSMD1	Yes	0.705	1.046	0.480	9.621	58.396	0.203	0.791	1.682	0.281
CSMD3	No	0.582	1.101		2.848	27.095		0.494	0.971
CSMD3	Yes	0.712	1.318	0.706	0.846	2.000	0.924	0.558	1.520	0.506
DNAH5	No	0.626	1.221		2.652	25.535		0.506	1.164
DNAH5	Yes	0.540	0.660	0.724	0.667	1.315	0.797	0.527	0.877	0.892
FAT3	No	0.619	1.198		2.684	25.486		0.523	1.197
FAT3	Yes	0.582	0.868	0.590	0.428	0.463	0.981	0.427	0.511	0.763
FAT4	No	0.655	1.250		2.718	26.117		0.529	1.194
FAT4	Yes	0.429	0.544	0.722	0.784	1.614	0.870	0.420	0.747	0.919
FLG	No	0.649	1.256		2.439	25.698		0.540	1.237
FLG	Yes	0.466	0.555	0.991	2.053	11.588	0.647	0.379	0.388	0.758
HMCN1	No	0.614	1.168		2.648	25.234		0.498	0.926
HMCN1	Yes	0.611	1.085	0.669	0.368	0.442	0.419	0.591	2.062	0.159
LRP1B	No	0.640	1.254		2.865	26.803		0.544	1.223
LRP1B	Yes	0.524	0.723	0.836	0.631	1.212	0.579	0.389	0.687	0.892
MUC16	No	0.580	1.186		1.155	6.308		0.499	1.064
MUC16	Yes	0.704	1.072	0.767	5.652	44.389	0.619	0.538	1.286	0.874
OBSCN	No	0.603	1.188		2.683	25.641		0.539	1.210
OBSCN	Yes	0.671	0.968	0.189	0.584	0.797	0.211	0.345	0.383	0.670
PCDH15	No	0.645	1.233		2.386	25.271		0.543	1.213
PCDH15	Yes	0.456	0.625	0.450	2.255	12.515	0.541	0.341	0.467	0.111
PCLO	No	0.636	1.222		2.299	24.906		0.535	1.197
PCLO	Yes	0.479	0.606	0.683	2.765	13.618	0.882	0.356	0.486	0.129
PIK3CA	No	0.520	0.925		0.946	5.834		0.425	0.936
PIK3CA	Yes	1.113	1.913	<0.001	9.890	57.716	<0.001	0.956	1.778	<0.001
RYR2	No	0.623	1.193		2.653	25.587		0.517	1.171
RYR2	Yes	0.561	0.924	0.825	0.708	1.333	0.131	0.467	0.827	0.689
SPTA1	No	0.643	1.230		2.724	25.691		0.543	1.211
SPTA1	Yes	0.451	0.591	0.580	0.406	0.523	0.557	0.325	0.392	0.260
SYNE1	No	0.654	1.190		2.925	26.804		0.564	1.257
SYNE1	Yes	0.473	1.027	0.137	0.424	0.570	0.415	0.321	0.380	0.081
TP53	No	0.680	1.295		3.179	27.936		0.601	1.307
TP53	Yes	0.448	0.677	0.125	0.333	0.484	0.015	0.280	0.313	0.014
TTN	No	0.640	1.178		1.268	6.978		0.475	0.699
TTN	Yes	0.576	1.128	0.054	3.918	35.803	0.230	0.558	1.542	0.088
ZFHX4	No	0.634	1.190		2.287	24.572		0.529	1.185
ZFHX4	Yes	0.462	0.855	0.372	2.951	14.867	0.650	0.360	0.466	0.411