USP46 Inhibits Cell Proliferation in Lung Cancer through PHLPP1/AKT Pathway

Figure 2

USP46 inhibited proliferation of human lung cancer cells. (a, b) Cell proliferation was measured by CCK-8 in H1299 cells (a) and A549 cells (b), and the rate of proliferation was compared between cells overexpressing USP46 (oeUSP46) and control cells (oeNC) (). means . (c, d) Protein levels or phosphorylation levels of indicated proteins were measured by WB in H1299 cells (c) and in A549 cells (d) overexpressing USP46 (oeUSP46) cells and control (oeNC) cells, and their quantifications are shown (). means . (e) Cell proliferation in H446 cells transfected with control siRNA (siNC) or USP46 siRNA (siUSP46-1 and siUSP46-2) was measured by CCK-8 (). means . (f) Levels of indicated proteins and phosphorylations were measured by WB in cells shown in (e), and their quantifications are shown (). means .

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