Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals

Figure 5

The protein-protein interaction (PPI) network was built by STRING database for AKT3 genes. Gray and red circles characterize downregulated and upregulated genes, respectively. Line thickness indicates the strength of the interaction. Dash and solid edges mean negative and positive correlation coefficient. Network nodes denote proteins’ posttranscriptional modifications or splice isoforms, and each node represents all the proteins produced by a single, protein-coding gene locus.