2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Polychlorinated Biphenyl Coexposure Alters the Expression Profile of MicroRNAs in the Liver Associated with Atherosclerosis

Figure 5

MicroRNA-mRNA interaction related to the cardiovascular system development and function network. miRNAs were used to link mRNA network related with cardiovascular system development and function to demonstrate the regulation role through IPA. Green and blue icons meant the downregulated mRNAs and miRNAs, respectively. Red and yellow icons meant the upregulated mRNAs and miRNAs, respectively. The solid arrow between miRNA and mRNAs denoted the interaction between miRNAs and mRNAs. Significantly upregulated or downregulated mRNAs: ( value < 0.05) or ( value < 0.05). Significantly upregulated genes or downregulated miRNAs: ( value < 0.05) or ( value < 0.05), respectively.