Development of an Immune Infiltration-Related Eight-Gene Prognostic Signature in Colorectal Cancer Microenvironment

Table 4

Univariate and multivariate Cox regression analyses in the GSE39582 dataset.

Characteristics	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age	1.455 (1.033-2.051)	0.031	1.590 (1.110-2.260)	0.010
Sex	1.310 (0.980-1.750)	0.068	NA	NA
BRAF mutation	1.111 (0.664-1.861)	0.688	NA	NA
KRAS mutation	1.361 (1.018-1.818)	0.037	1.420 (1.040-1.930)	0.025
TP53 mutation	1.197 (0.844-1.697)	0.312	NA	NA
MMR status	0.768 (0.471-1.252)	0.290	NA	NA
Pathologic T	2.005 (1.025-3.921)	0.042	1.510 (0.770-2.970)	0.229
Pathologic N	1.648 (1.228-2.213)	0.0008	1.090 (0.500-2.380)	0.822
Pathologic M	5.175 (3.621-7.395)	<0.0001	3.880 (2.510-5.990)	<0.0001
Tumor stage	1.767 (1.326-2.354)	0.0001	1.200 (0.520-2.800)	0.670
Risk score	2.718 (2.056-3.595)	<0.0001	2.420 (1.800-3.260)	<0.0001

NA: not available.