Circular RNAs in Gastric Cancer: Potential Biomarkers and Therapeutic Targets

Table 1

circRNA-miRNA-mRNA/protein network in GC.

Circular RNAs	Expression	Parental gene	Sponged miRNA	Targeted mRNA/protein	Related cell behaviors	Ref
hsa_circ_0006282	Up	/	miR-155	FBXO22	Proliferation, metastasis	[105]
hsa_circ_000684	Up	/	miR-186	ZEB1	Proliferation, migration, invasion, tube formation	[106]
hsa_circRNA_001569	Up	/	miR-145	NR4A2	Proliferation, apoptosis,	[107]
hsa_circRNA_102958	Up	/	miR-585	CDC25B	Proliferation, migration, invasion,	[108]
hsa_circRNA_104433	Up	ARPC1B	miR-497-5p	CDC25A	Proliferation, apoptosis	[109]
hsa_circ_0000291	Up	CD44	miR-183	ITGB1	Proliferation, migration	[110]
hsa_circ_0017639	Up	SFMBT2	miR-224-5p	USP3	Proliferation, migration	[111]
hsa_circ_0092306	Up	chr 11	miR-197-3p	PRKCB	Proliferation, apoptosis, migration, invasion,	[112]
Circ-ATAD1	Up	ATAD1	miR-140-3p	YY1/PCIF1	Proliferation, apoptosis, migration, invasion	[88]
Circ-ATXN7	Up	ATXN7	miR-4319	ENTPD4	Proliferation, apoptosis, migration	[113]
circ-PIP5K1A	Up	PIP5K1A	miR-671-5p	KRT80	Proliferation, migration, invasion, EMT process	[34]
circ-ERBB2	Up	ERBB2	miR-503,miR-637	CACUL1, MMP-19	Proliferation, apoptosis, migration, invasion	[46]
circ-NHSL1	Up	NHSL1	miR-1306-3p	SIX1/vimentin	Migration, invasion	[45]
circ-PVT1	Up	PVT1	miR-125b	E2F2	Proliferation	[43]
circ-HIPK3	Up	HIPK3	miR-124/29b	COL1A1/COL4A1/CDK6	Proliferation	[41]
circ-OSBPL10	Up	OSBPL10	miR-136-5p	WNT2	Proliferation, migration, invasion	[40]
circ-NOTCH1	Up	NOTCH	miR-449c-5p	MYC/NOTCH1	Proliferation, migration, invasion	[42]
circ-NRIP1	Up	NRIP1	miR-149-5p	AKT1/mTOR pathway	Proliferation, migration, invasion	[36]
ciRS-7	Up	Cdr1as	miR-7	PTEN/PI3K/AKT pathway	Proliferation, migration, invasion	[32]
circ-MAN2B2	Up	MAN2R2	miR-145	PI3K/AKT/JNK pathway	Proliferation, migration	[35]
circ-HIAT1	Down	HIAT1	miR-21	PTEN/PI3K/AKT/ERK pathway	Proliferation, apoptosis, EMT process	[33]
circ-ZFR	Down	ZFR	miR-130a/107	PTEN	Proliferation, apoptosis	[38]
circ-YAP1	Down	YAP1	miR-367-5p	p27 ^Kip1	Proliferation, invasion	[114]
circ-RHOBTB3	Down	RHOBTB3	miR-654-3p	p21	Proliferation, apoptosis	[115]
circ-LARP4	Down	LARP4	miR-424-5p	LATS1	Proliferation, invasion	[90]
circ-FAT1 (e2)	Down	FAT1	miR-548 g	RUNX1	Proliferation, invasion, migration.	[52]
circ-CCDC9	Down	CCDC9	miR-6792-3p	CAV1	Proliferation, migration, invasion	[116]
hsa_circ_0001368	Down	KLHL24	miR-6506-5p	FOXO3	Proliferation, invasion	[117]