Circular RNAs in Gastric Cancer: Potential Biomarkers and Therapeutic Targets

Table 2

Diagnostic efficiency of circRNAs in GC.

circRNAs	Samples	Clinical association	Diagnostic value				Sample size		Ref
			Sens	Spec	AUC	Cutoff value	Case	Control
Oncogenic
hsa_circ_0066444	Tissues	Lymphatic metastasis	0.7075	0.6887	0.7328	—	106	106	[71]
hsa_circRNA_102958	Tissues	TNM stage	0.61	0.86	0.74	—	30	30	[72]
hsa_circ-0000467	Tissues	TNM stage	0.705	0.648	0.790	—	51	51	[66]
Antioncogenic
hsa_circ_0067582	Tissues	Tissue CEA level and stages	0.552	0.750	0.671	10.61	96	96	[83]
hsa_circ_0005758		CEA level and perineural invasion	0.750	0.677	0.721	10.20
hsa_circ_0003159	Tissues	Gender, distal metastasis, and TNM stage	0.852	0.565	0.75	12.31	108	108	[82]
hsa_circ_0005654	Tissues	—	—	—	0.927	—	68	68	[79]
hsa_circ_00001649	Tissue	Pathological differentiation	0.711	0.816	0.834	0.2269225	76	76	[80]
hsa_circ_0000096	Tissues	Gender, invasion, and TNM stage	0.88	0.56	0.82	12.9	101	101	[65]
hsa_circ_0014717	Tissues	Tumor stage, distal metastasis, tissue CEA, and CA19-9 expression	0.5938	0.8125	0.696	12.14	96 GC	96	[11]
hsa_circ_0001895	Tissues	Tumor differentiation, Borrmann type, and tissue CEA expression	0.678	0.857	0.792	9.53	96 GC	96	[81]
hsa_circ_002059	Tissues	Distal metastasis, TNM stage, gender, and age	0.81	0.62	0.73	12.9	101	101	[84]
hsa_circ_0006633	Tissues	Distal metastasis and tissue CEA level	0.60	0.81	0.741	8.17	96	96	[85]
hsa_circ_0130810	Tissues	TNM stage and lymphatic metastasis	0.7742	0.6800	0.7481	1.443	28	28	[86]
hsa_circ_0006848	Plasma	Tumor differentiation and tumor size	—	—	0.733	—	30	30	[77]
hsa_circ_0000745	Plasma	TNM stage	0.855	0.45	0.683		60	60	[78]
hsa_circ_0000190	Tissues,	Tumor diameter, lymphatic and distal metastasis, TNM stage, and CA19-9	0.721	0.683	0.75	6.83	104	104	[67]
	Plasma	CEA	0.414	0.875	0.60	3.07	104	104
hsa_circ_0000181	Tissues, plasma	Tumor size, lymphatic metastasis, distal metastasis, and CA19-9	0.990	0.852	0.756	9.40	115	115	[73]
		Tumor differentiation and CEA level	99.0%	20.6%	0.582	7.27	102	105
hsa_circ_0000520	Tissues,	TNM stage	0.5357	0.8571	0.6129	—	56	56	[74]
	Plasma	CEA expression	0.8235	0.8444	0.8967	—	45	17
hsa_circ_0001821	Tissues,	Tumor depth and lymph node metastasis	—	—	0.792	—	80	80	[68]
	Plasma	—	—	—	0.872	—	30	30
hsa_circ_0001017	Tissues,	Age, tumor size, invasion, TNM stages, distal metastasis, and CEA levels	0.794	0.811	0.871	—	121	121	[75]
	Plasma	Gender, tumor size, differentiation, and distal metastasis	0.676	0.897	0.851	—
hsa_circ_0061276	Tissues,	Age, tumor size, TNM stages, distal metastasis, and CEA levels	0.913	0.507	0.764	—
	Plasma	Gender, tumor size, differentiation, and CEA levels	0.758	0.959	0.849	—
hsa_circ_0000419	Tissues,	Borrmann type and differentiation grade	0.552	0.677	0.642	8.14	96	96	[76]
	Plasma	Tumor stage, lymphatic and distal metastasis, venous and perineural invasion	0.682	0.884	0.840	4.9	44	43

Sens: sensitivity; Spec: specificity.