lncRNA RP11-838N2.3 Promoted Cisplatin Resistance in Lung Adenocarcinoma

Figure 6

Overexpression of RP11-838N2.3 could enhance migration ability of A549. (a) Compared with that of 0 h, the relative widths of 24 h (, , , and ), 48 h (, , , and ), and 72 h (, , , and ) all decreased obviously, and the mobility increased significantly. Compared with the A549 OE-NC group, the relative widths of the A549 OE group in 24 h (, ), 48 h (, ), and 72 h (, ) decreased evidently, and the mobility increased significantly. The result hinted that RP11-838N2.3 overexpression evidently promotes the migration of A549 cells. (b) Under the action of cisplatin drugs, RP11-838N2.3 overexpression still clearly promoted the migration of A549 cells. Compared with the that of the A549 OE-NC+2 μg/ml cisplatin group, the relative widths of the A549 OE+2 μg/ml cisplatin group in 24 h (, ), 48 h (, ), and 72 h (, ) decreased evidently and the mobility increased clearly. .

(a)

(b)