Gypenoside Inhibits Endothelial Cell Apoptosis in Atherosclerosis by Modulating Mitochondria through PI3K/Akt/Bad Pathway

Figure 4

Gypenoside decreases caspase 3 activity and the expression of mitochondrial fission and fusion proteins in the aorta. (a) Caspase 3 activity, as analyzed by the corresponding kit in the normal, ApoE−/−, gypenoside, and simvastatin groups. Results are expressed as the of four different experiments (). (b, c) Western blot result of DRP1 and MFN2 expression in the aorta; bar chart results are expressed as the of four different experiments (); and between each group. (d) Immunofluorescence results of DRP1 and MFN2 expression in the aorta.

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