Astragalus Polysaccharide Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Damage and Mitochondrial Dysfunction

Figure 2

APS pretreatment protects HK-2 cells from cisplatin exposure. (a) HK-2 cell viability was measured by CCK8. Cells were incubated with different concentrations of cisplatin for 24 h from 0 (control) to 50 μmol/L. (b) Cell viability of HK-2 cells treated with APS at different concentrations for 24 h from 0 (control) to 200 μg/mL. (c) Cell viability of HK-2 cells treated with APS and cisplatin. HK-2 cells were pretreated with APS at different concentrations for 24 h and then were treated with 20 μmol/L cisplatin for 24 h. Values are means ± SEM (n = 3). , versus control; , versus the cisplatin alone-treated group.

(a)

(b)

(c)