Multiple Intravenous Injections of Valproic Acid-Induced Mesenchymal Stem Cell from Human-Induced Pluripotent Stem Cells Improved Cardiac Function in an Acute Myocardial Infarction Rat Model

<div>Morphology transformation during hiPSC-MSC induction. (a) Undifferentiated human iPSC colony. (b) hiPSCs transformed to larger cuboidal-shaped epithelial-like cells after eight-day VPA induction. (c) After the first passage, the morphology of differentiating cells transformed from cuboidal to olive shape. (d) Large spindle-shaped cells appeared in the second passage. (e) Small spindle-shaped cells grew out from cell mess. (f) On the passage six, more than 90% of the adherent cells maintained a small spindle-shaped morphology 100×.</div>

BioMed Research International

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Figure 1: Multiple Intravenous Injections of Valproic Acid-Induced Mesenchymal Stem Cell from Human-Induced Pluripotent Stem Cells Improved Cardiac Function in an Acute Myocardial Infarction Rat Model 

Figure 1 | Multiple Intravenous Injections of Valproic Acid-Induced Mesenchymal Stem Cell from Human-Induced Pluripotent Stem Cells Improved Cardiac Function in an Acute Myocardial Infarction Rat Model 