Long Noncoding RNA SOX2-OT: Regulations, Functions, and Roles on Mental Illnesses, Cancers, and Diabetic Complications

Figure 1

Long noncoding RNA SOX2-OT’s regulations, functions, and roles on mental illnesses, cancers, and diabetic complications. Transcription activators ((A) SOX2, IRF4, AR, and SOX3) can upregulate SOX2-OT expression, but transcription inhibitors ((B) NSPc1, MTA3, and YY1) and miRNAs ((C) miR-211 and miR-375) downregulate SOX2-OT expression. D. SOX2-OT upregulates SOX2 expression in cancer cells. (E) SOX2-OT downregulates SOX2 expression in neural stem cells. SOX2-OT can control miRNA levels via serving as a miRNA sponge (F) and affect transcription via serving as a bridge between epigenetic factors and DNA (G). (H) SOX2-OT SNPs are associated with mental illnesses. (I) SOX2-OT is a biomarker for cancers.