Long Noncoding RNA SOX2-OT: Regulations, Functions, and Roles on Mental Illnesses, Cancers, and Diabetic Complications

Table 1

SOX2-OT regulates SOX2 expression.

Regulation	Intermediator	Cell model	Cellular function	Reference
Increase	miR-200c	Bladder cancer	Metastasis and stemness	Zhan et al. [17]
Increase	Unknown	Esophageal squamous cell carcinoma	Metastasis and stemness	Du et al. [56]
Decrease	Unknown	Septic cardiomyopathy	Mitochondrial dysfunction	Chen et al. [16]
No effect	Unknown	Esophageal squamous cell carcinoma	Cell proliferation	Wu et al. [15]
Increase	Unknown	Cholangiocarcinoma	Proliferation and metastasis	Wei et al. [57]
Decrease	Promoter-enhancer loop	Embryonic development	Neural differentiation	Messemaker et al. [7]
Increase	miR-200 family	Pancreatic ductal adenocarcinoma	EMT, stemness, invasion, and metastasis	Li et al. [18]
Decrease	YY1	Embryonic development	Represses neural progenitor proliferation and promotes neuronal differentiation	Knauss et al. [20]
Increase	Unknown	Pancreatic ductal adenocarcinoma	Proliferation and tumor growth	Zhang et al. [19]
Increase	Unknown	Lung cancer	Proliferation, migration, invasion, and stemness	Wang et al. [38]
Increase	Unknown	Breast cancer	Proliferation	Askarian-Amiri et al. [58]

Note: EMT: epithelial-mesenchymal transition; YY1: Yin Yang-1.