Long Noncoding RNA SOX2-OT: Regulations, Functions, and Roles on Mental Illnesses, Cancers, and Diabetic Complications

Table 2

SOX2-OT is a miRNA sponge.

miRNA	Cancer	Target	Cellular function	Reference
hsa-mir-192-5p, hsa-mir-215-5p, hsa-mir-204-5p, hsa-mir-205-5p, hsa-mir-338-3p, hsa-mir-375	Esophageal squamous cell carcinoma	Unknown	Unknown	Tian et al. [23]
miR-200c	Bladder cancer	SOX2	Increases bladder cancer cell stemness and metastasis	Zhan et al. [17]
miR-146b-5p	Nasopharyngeal carcinoma	HNRNPA2B1	Increases proliferation and metastasis; decreases apoptosis	Zhang and Li [59]
miR-369-3p	Prostate cancer	CFL2	Increases proliferation and migration	Wo et al. [60]
miR-363	Ewing’s sarcoma	FOXP4	Increases proliferation and invasion; decreases apoptosis	Ma et al. [61]
miR-132	Non-small-cell lung cancer	ZEB2	Increases proliferation, migration, invasion, and EMT	Zhang et al. [62]
miR-211	Pheochromocytoma	MCL-1 isoform 2	Increases cell viability, migration, and invasion; decreases apoptosis and autophagy	Yin et al. [49]
miR-194-5p	Gastric cancer	AKT2	Promotes proliferation, metastasis, invasion, migration, and EMT	Wei et al. [63], Qu et al. [64]
miR-200 family	Pancreatic ductal adenocarcinoma	SOX2	Promotes EMT and stem cell-like properties	Li et al. [18]
miR-194-5p, miR-122	Glioma	SOX3	Increases proliferation, migration, and invasion; decreases apoptosis	Su et al. [65]

Note: EMT: epithelial-mesenchymal transition; Sox2: SRY-box transcription factor 2; HNRNPA2B1: heterogeneous nuclear ribonucleoprotein A2/B1; CFL2: cofilin 2; FOXP4: forkhead box P4; ZEB2: zinc finger E-box binding homeobox 2; MCL1 Isoform 2: myeloid cell leukemia sequence 1 isoform 2; AKT2: AKT serine/threonine kinase 2; SOX3: SRY-box transcription factor 3.