Long Noncoding RNA SOX2-OT: Regulations, Functions, and Roles on Mental Illnesses, Cancers, and Diabetic Complications

Table 3

SOX2-OT is regulated at the transcriptional and posttranscriptional levels.

Factor	Regulatory effect	Cell model	Reference
NSPc1	Represses transcription	Glioma cells	Liang et al. [26]
MTA3	Represses transcription	Esophageal squamous cell carcinoma cells	Du et al. [56]
SOX2	Promotes transcription	Esophageal squamous cell carcinoma cells	Wu et al. [15]
IRF4	Promotes transcription	Cholangiocarcinoma cells	Wei et al. [57]
YY1	Represses transcription	Pancreatic ductal adenocarcinoma cells	Zhang et al. [19]
AR	Promotes transcription	Embryonic neural stem cells	Tosetti et al. [66]
SOX3	Promotes transcription	Glioblastoma stem cells	Su et al. [65]
miR-211	Downregulates expression by directly binding to SOX2-OT	Embryonal carcinoma stem cells (NT-2)	Shafiee et al. [67]
miR-375	Downregulates expression by directly binding to SOX2-OT	Embryonal carcinoma stem cells (NT-2)	Shafiee et al. [68]

Note: NSPc1: nervous system polycomb 1; MTA3: metastasis-associated protein 3; IRF4: interferon regulatory factor 4; YY1L Yin Yang-1; ARL androgen receptor; Sox3: SRY-box transcription factor 3.