CD44, IL-33, and ST2 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility in the Chinese Population

Table 4

Association of CD44 rs187115 genotype with clinical characteristics in HCC patients.

Characteristics	rs187115			value	rs187115		value	rs187115		value
	AA	AG	GG		AG	GG		AA	AG+GG
Age (year)
<40	147	57	6		57	6		147	63
≥40	235	106	14	0.589	106	14	0.659	235	120	0.351
Gender
Male	55	20	3		20	3		55	23
Female	327	143	17	0.800	143	17	0.728	327	160	0.563
BMI (kg/m^2)
<18.5	43	16	4		16	4		43	20
18.5-23.9	242	109	14		109	14		242	123
≥24	97	38	2		38	2		97	40
BCLC stage
A+B stage	211	83	11		83	11		211	94
C+D stage	171	80	9	0.634	80	9	0.730	171	89	0.373
Smoking status
No	230	100	12		100	12		230	112
Yes	152	63	8	0.973	63	8	0.907	152	71	0.840
Alcohol drinker
No	251	107	15		107	15		251	122
Yes	131	56	5	0.692	56	5	0.402	131	61	0.838
Metastasis
No	272	181	17		181	17		272	198
Yes	71	21	3	0.008	21	3	0.545	71	24	0.002
Liver cirrhosis
Absent	116	53	2		53	2		116	55
Present	266	110	18	0.117	110	18	0.038	266	128	0.955
HBV infection
HbsAg (−)	37	18	1		18	1		37	19
HbsAg (+)	339	141	18	0.675	141	18	0.419	339	159	0.754
HCV infection	6	4	1		4	1		6	5
AST
Negative	204	79	9		79	9		204	88
Positive	178	84	11	0.460	84	11	0.770	178	95	0.226
ALT
Negative	235	163	12		163	12		235	175
Positive	147	67	8	≤0.001	67	8	0.309	147	75	0.031
GGT
Negative	130	66	8		66	8		130	74
Positive	252	97	12	0.322	97	12	0.966	252	109	0.132
AFP
Negative	154	62	11		62	11		154	73
Positive	228	101	9	0.343	101	9	0.144	228	120	0.580

ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: γ-glutamyl transpeptidase; AFP: alpha fetoprotein.