CD44, IL-33, and ST2 Gene Polymorphisms on Hepatocellular Carcinoma Susceptibility in the Chinese Population

Table 5

Association of IL-33 rs1929992 genotype with clinical characteristics in HCC patients.

Characteristics	rs1929992			value	rs1929992		value	rs1929992		value
	AA	GA	GG		GA	GG		AA	GA+GG
Age(year)
Range	13-83	10-89	24-87		10-89	24-87		13-83	10-89
Mean	52.6	52.1	54.3		52.1	54.3		52.6	53.1
<40	23	51	15		51	15		23	663
≥40	146	210	120	0.056	210	120	0.053	146	330	0.057
Gender
Male	138	233	116		233	116		138	349
Female	31	28	19	0.082	28	19	0.329	31	47	0.051
BMI (kg/m^2)
<18.5	15	32	14		32	14		15	46
18.5-23.9	112	164	90		164	90		112	254
≥24.0	42	65	31	0.816	65	31	0.735	42	96	0.182
BCLC stage
A+B stage	90	145	71		145	71		90	216
C+D stage	79	116	64	0.821	116	64	0.575	79	180	0.778
Smoking status
No	98	166	80		166	80		98	246
Yes	71	95	55	0.460	95	55	0.453	71	150	0.357
Alcohol drinker
No	114	178	88		178	88		114	266
Yes	55	83	47	0.831	83	47	0.398	55	130	0.948
Metastasis
No	143	218	119		218	119		143	337
Yes	26	43	16	0.470	43	16	0.221	26	59	0.882
Family history of cancer
No	145	219	121		219	121		145	340
Yes	24	42	14	0.302	42	14	0.121	24	56	0.985
Liver cirrhosis
Absent	47	89	35		89	35		47	124
Present	122	172	100	0.173	172	100	0.096	122	272	0.404
HBV infection
HbsAg (−)	18	23	14		23	14		18	37
HbsAg (+)	146	225	128		225	128		146	353
HCV infection	5	3	3	0.684	3	3	0.792	5	6	0.379
AST
Negative	82	135	76		135	76		82	211
Positive	87	126	59	0.402	126	59	0.387	87	185	0.300
ALT
Negative	97	155	94		155	94		97	249
Positive	72	106	41	0.066	106	41	0.056	72	147	0.221
GGT
Negative	65	106	56		106	56		65	162
Positive	104	155	79	0.855	155	79	0.868	104	234	0.587
AFP
Negative	67	108	53		108	53		67	161
Positive	102	153	82	0.886	153	82	0.684	102	235	0.822

ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl transpeptidase; AFP, alpha fetoprotein.