Differences in the Clinical Characteristics of Early- and Late-Onset Asthma in Elderly Patients

Table 1

Difference in demographics and comorbidities between EOA and LOA in elderly subjects.

Variables	Total (n = 176)	EOA (n = 92)	LOA (n = 84)	value
Age	70.98 ± 6.49	70.3 ± 77.10	71.65 ± 5.702	0.001
Female	94 (53.4%)	51	43	0.573
Rural region	64 (36.4%)	31	33	0.441
Smoking status
Never	104 (59.1%)	60	44	0.084
Former	41 (23.3%)	20	21	0.609
Current	31 (19.3%)	12	19	0.096
BMI, kg/m^2	22.57 ± 2.43	22.31 ± 2.27	22.85 ± 2.58	0.140
FH asthma	78 (44.4%)	48	30	0.028
Atopy	42 (23.9%)	28	14	0.032
Allergic rhinitis	76 (43.8%)	48	28	0.012
Allergic eczema	50 (26.9%)	32	18	0.050
COPD	38/29 (21.6%)	13/10	25/19	0.012
Bronchiectasis	36 (20.5%)	18	18	0.760
CVD	51 (29.0%)	28	23	0.656
Depression	13 (7.4%)	7	6	0.906
Anxiety	56 (31.8%)	33	23	0.227
IgE	118.41 ± 84.44	151.27 ± 99.22	82.43 ± 41.64	0.001
FeNO, mean (SD) ppb	38.64 ± 17.98	45.58 ± 21.85	31.05 ± 6.83	0.001
Controlled	61 (34.7%)	30	31	0.550
Uncontrolled	47 (26.7%)	26	21	0.625
Partly controlled	68 (38.6%)	36	32	0.888
Asthma severity
Mild	58 (33.0%)	30	28	0.919
Moderate	78 (44.3%)	44	41	0.252
Severe	30 (17.0%)	18	15	0.784
Medications
Number on ICS/LABA	153 (86.9%)	81	72	0.647
Number on high-dose ICS/LABA	32 (18.2%)	11	21	0.025
Number on LAMA
Maintenance oral prednisolone	7 (4.0%)	4	3	0.792
Maintenance oral theophylline	47 (26.7%)	20	27	0.119
Unscheduled doctor visit in past one year	45 (25.6%)	25	20	0.609
ED (<24 h) in past one year	41 (23.3%)	23	18	0.576
Hospitalizations (>24 h) in past one year	36 (20.5%)	19	17	0.946
History of intubation	15 (8.5%)	8	7	0.931

All parametric data are expressed as mean (standard deviation) unless stated otherwise.