Chronic Active Epstein-Barr Virus-Associated Enteritis: CT Findings and Clinical Manifestation

Table 2

Endoscopic and pathologic findings of the three CAEAE patients.

Case	Endoscopy	Biopsy samples	HE stain	Immunohistochemistry	EBER
1	Numerous irregular ulcers in the colon	Hepatic flexure of colon, transverse colon, descending colon, sigmoid colon	Lymphatic follicles in the lamina propria, crypt abscess in some glands, aggregation of atypical lymphoid cells	CD3, CD7+ Ki-67+<5%	Colon positive
2	Numerous shallow and small ulcers in the colon	Ascending colon, transverse colon, descending colon, rectum, esophagus, throat	Tissue granulation, atypical lymphocyte infiltration	Colon:CD2, CD3, CD4, CD8, TIA-1, GrB+. Ki-67(+, 20%). Throat:CD2, CD3, CD7, CD56(+). Ki-67(+, 40%).	Colon and esophagus positive
3	Numerous irregular ulcers in the colon	Ileocecal junction, ascending colon, transverse colon, descending colon	Granulomatous tissue and lymphoid tissue hyperplasia, atypical lymphocyte infiltration	CD3, CD20, Pax-5, CD4, CD8(+), Ki-67(+, 20%).	Colon positive