Structure-Activity Relationship (SAR) and in vitro Predictions of Mutagenic and Carcinogenic Activities of Ixodicidal Ethyl-Carbamates

Table 2

Profiling results of Structure-Activity Relationship (SAR) analysis of ixodicidal ethyl-carbamates.

Chemical or biological mechanism	LQM 919	LQM 996
DNA binding by OECD	No alert found	No alert found
Estrogen receptor binding	Non binder, without OH or NH2 group	Non binder, without OH or NH2 group
Protein binding by OECD	No alert found	No alert found
Superfragments	No superfragment	No superfragment
Toxic hazard classification by Cramer (original)	High (class III)	High (class III)
US-EPA new chemical categories	Neutral organics	Neutral organics