In Vitro Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles against Feline Infectious Peritonitis Virus and Pharmacokinetics Study in Cats

Table 4

Percentages of protection in curcumin and Cur-CS nanoparticle treatments with virus in different exposure methods at different concentrations.

Compound	Concentration (μM)	Pretreatment		Cotreatment		Posttreatment
		48 h	72 h	48 h	72 h	48 h	72 h
Curcumin	2.5	^a	^a	^a	^a	^a	^a
	5	^a	^ab	^b	^b	^a	^a
	10	^ab	^a	^d	^c	^b	^a
	20	^c	^bc	^e	^c	^bc	^a
Cur-CS nanoparticles	2.5	^a	^a	^a	^a	^a	^a
	5	^b	^ab	^c	^b	^a	^a
	10	^c	^c	^e	^c	^c	^a
	20	^d	^d	^f	^d	^d	^b

Data are presented as () and analysed using one-way ANOVA and post hoc Duncan multiple test. For each time interval, means within a column with different roman letters were significantly different () from each other. Cur-CS: curcumin-encapsulated chitosan.