In Vitro Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles against Feline Infectious Peritonitis Virus and Pharmacokinetics Study in Cats

Table 9

Pharmacokinetic parameters of curcumin and Cur-CS nanoparticles given s.i.d. and b.i.d. orally in healthy cats.

Formulation	Curcumin	Cur-CS nanoparticles
Single dosing (s.i.d.)
(ng/mL)
(h)	3	4
AUC0-12 (ng/mL h)
AUC0-∞ (ng/mL h)
Two dosing (b.i.d.)
(ng/mL)
(h)	4	4
AUC0-12 (ng/mL h)
AUC0-24 (ng/mL h)

Data are presented as () and analysed using paired sample -test. For each parameter, means with an asterisk () were significantly () different from the control (curcumin). Cur-CS: curcumin-encapsulated chitosan.