Plant-Produced Monoclonal Antibody as Immunotherapy for Cancer

Table 1

Examples of plant production systems used for cancer immunotherapy [28].

Malignancy	Antigen/plant system used
Hepatitis B virus-induced hepatocellular carcinoma	HBsAg expressed in transgenic plants
Hepatitis C virus-induced hepatocellular carcinoma	E7 protein expressed in chloroplasts
Non-Hodgkin’s lymphoma	Full IgG expressed in TMV-based expression system
Breast cancer	PVX nanoparticles expressing HER2 epitope
Solid tumors	PapMV nanoparticles
Lung melanoma	CPMV nanoparticles
Solid tumors	TMV nanoparticles displaying cRGD

CPMV: cowpea mosaic virus; HBsAg: hepatitis B virus surface antigen; PapMV: papaya mosaic potexvirus; PVX: potato virus X; TMV: tobacco mosaic virus.