Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis

Table 1

Main characteristics of the included studies. RR, relative risk; OR, odds ratio; CI, confidence interval; BMI: body mass index; CHD, coronary heart disease; COPD, chronic obstructive pulmonary disease; NR: not reported.

Author/year of publication	Country	No. of case/control	Follow-up period	Source of controls	Site of OA	Study subtype	Adjusted factors	Adjusted OR/RR (95% CI)
Zhou/2017	China	281/3066	2008-2013	Hospital	Knee	Cross-sectional	Age (as a continuous variable), WHR (as a continuous variable), gender, physical workload, physical exercise, smoking, and drinking	1.34 (1.15–1.55)
Frey/2017	Switzerland	19,590/19,590	1995-2014	Population	Hand	Case-control	Smoking, alcohol consumption, diabetes mellitus, hypertension, COPD, hand fractures, hormone replacement therapy, osteoporosis, and statin use	1.37 (1.28-1.47)
Xie/2017	China	1669/4095	2013-2014	Hospital	Knee	Cross-sectional	Age, gender, activity level, smoking status, alcohol drinking status, and educational background	1.33 (1.18–1.50)
Gil/2017	UK	143/707	1988-1989	Population	Hand	Cohort	Age, any current medication, diabetes medication, statin use, hormone replacement therapy (HRT), previous CVD, menopause, smoking, body mass index (BMI), and systolic and diastolic blood pressure	1.75 (0.82–3.70)
Engstrom/2009	Sweden	89/5082	1991-1994	Population	Knee and hip	Cohort	Age, gender, smoking, physical activity, and CRP	0.9 (0.5-1.4)
Han/2013	Korea	270/1964	2008-2009	Population	Knee	Cohort	Age, height, exercise, alcohol intake, and smoking	1.04 (0.74, 1.47)
Inoue/2011	Japan	52/243	1995-2005	Population	Knee	Case-control	NR	1.21 (0.85-1.65)
Hussain/2014	Australia	660/19,208	2003-2007	Population	Knee	Cohort	Age, gender, country of birth, level of education, physical activity and BMI	0.99 (0.83–1.18)
Sturmer/1998	Germany	809/809	NR	Hospital	Knee	Case-control	NR	1.61 (1.06-2.47)