Longitudinal Analysis of Prevalence and Risk Factors of Rifampicin-Resistant Tuberculosis in Zhejiang, China
Table 1
Resistance to anti-TB drugs among new cases and previously treated cases in 4 surveys of Zhejiang province.
1998
2003
2008
2013
Total
New cases
PTC
New cases
PTC
New cases
PTC
New cases
PTC
New cases
PTC
n (%)
n (%)
n (%)
n (%)
n (%)
n (%)
n (%)
n (%)
n (%)
n (%)
Total
806
148
832
153
842
96
853
102
3333
499
Resistance to at least one drug
119 (14.8)
87 (58.8)
220 (26.4)
80 (52.3)
224 (26.6)
48 (50.0)
192 (22.5)
48 (47.1)
755 (22.7)
263 (52.7)
Monodrug resistance
INH
22 (2.7)
11 (7.4)
33 (4.0)
7 (4.6)
29 (3.4)
4 (4.2)
37 (4.3)
6 (5.9)
121 (3.6)
28 (5.6)
RIF
13 (1.6)
8 (5.4)
7 (0.8)
4 (2.6)
8 (1.0)
2 (2.1)
8 (0.9)
3 (2.9)
36 (1.1)
17 (3.4)
SM
2 (0.2)
1 (0.7)
98 (11.8)
13 (8.5)
117 (13.9)
6 (6.3)
75 (8.8)
5 (4.9)
292 (8.8)
25 (5.0)
EMB
29 (3.6)
7 (4.7)
8 (1.0)
1 (0.7)
3 (0.4)
0 (0.0)
7 (0.8)
2 (2.0)
47 (1.4)
10 (2.0)
RIF-resistance
51 (6.3)
65 (43.9)
41 (4.9)
53 (34.6)
43 (5.1)
32 (33.3)
44 (5.2)
30 (29.4)
179 (5.4)
180 (36.1)
MDR#
35 (4.3)
52 (35.1)
30 (3.6)
45 (29.4)
28 (3.3)
28 (29.2)
35 (4.1)
26 (25.5)
128 (3.8)
151 (30.3)
Resistance to four 1st line drugs
9 (1.1)
18 (12.2)
11 (1.3)
10 (6.5)
7 (0.8)
12 (12.5)
13 (1.5)
10 (9.8)
40 (1.2)
50 (10.0)
Susceptibility
687 (85.2)
61 (41.2)
611 (73.4)
73 (47.7)
618 (73.4)
48 (50.0)
661 (77.5)
54 (52.9)
2577 (77.3)
236 (47.3)
INH: isoniazid; RIF: rifampicin; EMB: ethambutol; SM: streptomycin; PTC: previously treated cases. Defined as resistant to at least RIF. #Defined as resistant to at least INH and RIF.
