[Retracted] α₁-Adrenergic Receptor Blockade by Prazosin Synergistically Stabilizes Rat Peritoneal Mast Cells

Figure 7

Effects of α₁-adrenergic receptor antagonist on adrenaline-induced inhibition of mast cell degranulation. (a) Differential-interference contrast (DIC) microscopic images were taken after exocytosis was externally induced by compound 48/80 in mast cells incubated in the external solutions containing no drug (A), 1 mM adrenaline (B), or 1 mM adrenaline in the presence of 1 μM prazosin (C). (b) After exocytosis was induced in mast cells incubated in the external solutions containing no drug and 1 mM adrenaline with or without the presence of 1 μM prazosin, the numbers of degranulating mast cells were expressed as percentages of the total mast cell numbers in selected bright fields. ^# vs. incubation in the external solution alone. vs. incubation in the external solution containing 1 mM adrenaline. Values are . Differences were analyzed by ANOVA followed by Tukey’s test.

(a)

(b)