Altered Bioavailability of Nitric Oxide and L-Arginine Is a Key Determinant of Endothelial Dysfunction in Preeclampsia

Table 3

Linear regression analysis of potential biomarkers associated with the risk of preeclampsia after adjusting for maternal age, BMI, and gestational age.

Dependent variable	Parameter	Mild preeclampsia		Severe preeclampsia
		coefficient	value	coefficient	value
Systolic blood pressure	Nitric oxide (μmol/L)	-0.160	0.214	0.313	0.106
	L-Arginine (μmol/L)	-0.034	0.787	0.181	0.341
	ADMA (μmol/L)	0.137	0.316	0.454	0.036
	3-Nitrotyrosine (mmol/L)	-0.165	0.195	0.303	0.128
	L-Arginine/ADMA ratio	-0.052	0.695	-0.066	0.741
Diastolic blood pressure	Nitric oxide (μmol/L)	-0.153	0.263	0.247	0.128
	L-Arginine (μmol/L)	-0.204	0.132	0.123	0.443
	ADMA (μmol/L)	-0.084	0.564	0.304	0.098
	3-Nitrotyrosine (mmol/L)	-0.171	0.207	0.253	0.129
	L-Arginine/ADMA ratio	-0.155	0.269	-0.005	0.977

ADMA: asymmetric dimethylarginine. Statistically significant level was set at a value < 0.05.