MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA

Figure 2

miR-587 suppressed HCC cell proliferation. (a) The transfection efficiency of miR-587 mimic () and inhibitor (). The MTT assay showed that miR-587 upregulation (b) suppressed the cell viability of SMMC-7721 cells, whereas miR-587 downregulation (c) fostered the cell viability (both ). Flow cytometry analysis showed that the number of SMMC-7721 cells at G1 phase increased and those at S phase decreased in the miR-587 mimic group (d) (, , respectively). The number of SMMC-7721 cells at G1 phase decreased and those at S phase increased in the miR-587 inhibitor group (e) (, , respectively). , . miR: microRNA.

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