Research Article
Cognitive Protective Mechanism of Crocin Pretreatment in Rat Submitted to Acute High-Altitude Hypoxia Exposure
Figure 2
Crocin pretreatment ameliorated learning and memory impairment in acute high-altitude hypoxia rats (). Ctr: control group, with saline. AHH: rats exposed under hypoxia for 3 days at 4200 m. LHG, MHG, HHG: rats exposed under hypoxia for 3 days at 4200 m after pretreatment by 25 mg/kg/d, 50 mg/kg/d, and 100 mg/kg/d of crocin. (a) Characteristic swimming direction of the rats during the Morris water maze (MWM) test. (A) Ctr; (B) AHH; (C) LHG; (D) MHG; (E) HHG. (b) The percentage of time spent in the target quadrant. (c) Traveled distance. # versus Ctr, versus AHH, ■ versus Ctr, △ versus HLG, and ▲ versus HMG.
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