Research Article
Cognitive Protective Mechanism of Crocin Pretreatment in Rat Submitted to Acute High-Altitude Hypoxia Exposure
Figure 5
Crocin pretreatment improves the expression of NRF1 and TFAM in rat’s hippocampal cells under acute high-altitude hypoxia. Ctr: control group, with saline. AHH: rats exposed under hypoxia for 3 days at 4200 m. LHG, MHG, HHG: rats exposed under hypoxia for 3 days at 4200 m after pretreatment by 25 mg/kg/d, 50 mg/kg/d, and 100 mg/kg/d of crocin. (a, b) Immunohistochemical staining of NRF1 and TFAM expression in the CA1 region of the hippocampus (). # versus Ctr, versus AHH, ■ versus Ctr, △ versus HLG, and ▲ versus HMG.
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