Research Article
Cognitive Protective Mechanism of Crocin Pretreatment in Rat Submitted to Acute High-Altitude Hypoxia Exposure
Figure 7
Crocin pretreatment decreased the Bcl-2, Bax, and caspase-3 expression in the hippocampus of rats under acute high-altitude hypoxia (). Ctr: control group, with saline. AHH: rats exposed under hypoxia for 3 days at 4200 m. LHG, MHG, HHG: rats exposed under hypoxia for 3 days at 4200 m after pretreatment by 25 mg/kg/d, 50 mg/kg/d, and 100 mg/kg/d of crocin. (a, b) Western blotting detection of Bcl-2, Bax, and caspase-3 protein expression in the hippocampus. (c) Bcl-2, Bax, and caspase-3 mRNA expression by qRT-PCR in the hippocampus. # versus Ctr, versus AHH, ■ versus Ctr, △ versus HLG, and ▲ versus HMG.
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