Research Article
Cognitive Protective Mechanism of Crocin Pretreatment in Rat Submitted to Acute High-Altitude Hypoxia Exposure
Figure 8
Crocin pretreatment decreased the Bcl-2, Bax, and caspase-3 expression in the CA1 region of hippocampal neurons under acute high-altitude hypoxia (). Ctr: control group, with saline. AHH: rats exposed under hypoxia for 3 days at 4200 m. LHG, MHG, HHG: rats exposed under hypoxia for 3 days at 4200 m after pretreatment by 25 mg/kg/d, 50 mg/kg/d, and 100 mg/kg/d of crocin. (a, b) Proteins were expressed in the cytoplasm, showing a dark brown color in positive staining areas. # versus Ctr, versus AHH, ■ versus Ctr, △ versus HLG, and ▲ versus HMG.
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