Research Article
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma
Table 1
Univariate and multivariate Cox regression analyses of prognostic parameters in validation cohort.
| | Univariate Cox regression | Multivariate Cox regression | HR (95% CI) | value | HR (95% CI) | value |
| Age (≥16 y vs. <16 y) | 0.92 (0.93-1.01) | 0.10 | 0.94 (0.87-1.02) | 0.14 | Gender (female vs. male) | 2.01 (0.80-5.03) | 0.14 | — | — | Location (femur/tibia vs. other) | 1.36 (0.42-4.34) | 0.74 | — | — | Lung metastasis at diagnosis (yes vs. no) | 2.36 (1.28-7.50) | <0.01 | 1.69 (0.72-5.73) | 0.02 | Enneking stage (IIB-III vs. I-IIA) | 3.32 (0.75-10.64) | <0.01 | 4.16 (1.34-12.90) | <0.01 | PLOD1 (high vs. low) | 1.20 (0.99-1.51) | <0.01 | 1.23 (1.02-1.47) | 0.03 | PLOD2 (high vs. low) | 1.11 (0.92-1.34) | 0.28 | — | — | PLOD3 (high vs. low) | 0.89 (0.63-1.20) | 0.45 | — | — |
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