PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma

Table 1

Univariate and multivariate Cox regression analyses of prognostic parameters in validation cohort.

	Univariate Cox regression		Multivariate Cox regression
	HR (95% CI)	value	HR (95% CI)	value
Age (≥16 y vs. <16 y)	0.92 (0.93-1.01)	0.10	0.94 (0.87-1.02)	0.14
Gender (female vs. male)	2.01 (0.80-5.03)	0.14	—	—
Location (femur/tibia vs. other)	1.36 (0.42-4.34)	0.74	—	—
Lung metastasis at diagnosis (yes vs. no)	2.36 (1.28-7.50)	<0.01	1.69 (0.72-5.73)	0.02
Enneking stage (IIB-III vs. I-IIA)	3.32 (0.75-10.64)	<0.01	4.16 (1.34-12.90)	<0.01
PLOD1 (high vs. low)	1.20 (0.99-1.51)	<0.01	1.23 (1.02-1.47)	0.03
PLOD2 (high vs. low)	1.11 (0.92-1.34)	0.28	—	—
PLOD3 (high vs. low)	0.89 (0.63-1.20)	0.45	—	—