BioMed Research International / 2020 / Article / Tab 1

Review Article

D-Lactic Acid as a Metabolite: Toxicology, Diagnosis, and Detection

Table 1

Enzymes involved in D-lactate metabolism.

Name of enzymeEC numberSubstratesProductsProducing organismsReferences

D-Lactate dehydrogenaseEC 1.1.1.28D-Lactate + NAD+Pyruvate + NADHFungi Phytophthora undulata, Pythium debaryanum, and Sapromyces elongatus, bacteria Lactobacillus delbrueckii, Lactobacillus bulgaricus, Escherichia coli, Fusobacterium nucleatum, and Pseudomonas aeruginosa[2730]
D-Lactate dehydrogenase (cytochrome)EC 1.1.2.4D-Lactate + 2 ferricytochrome cPyruvate + 2 ferrocytochrome c + 2H+Plant Arabidopsis thaliana, yeast Hansenula polymorpha and Saccharomyces cerevisiae[3133]
D-Lactate dehydrogenase (cytochrome c-553)EC 1.1.2.5D-Lactate + 2 ferricytochrome c-553Pyruvate + 2 ferrocytochrome c-553 + 2H+Bacterium Desulfovibrio vulgaris[35]
D-Lactate dehydratase (also glyoxalase 3)EC 4.2.1.130D-LactateMethylglyoxal + H2OHomo sapiens[36]