BioMed Research International / 2020 / Article / Tab 3

Review Article

D-Lactic Acid as a Metabolite: Toxicology, Diagnosis, and Detection

Table 3

Biochemical parameters of blood in D-lactate exposure case reports.

Assay typePrinciple of selectivity to D-isomer over L-isomerReferences

Electrochemical biosensorSelectivity given by enzyme D-lactate dehydrogenase[97]
Electrochemical (amperometric) biosensorSelectivity given by enzyme D-lactate oxidoreductase (cytochrome)[98]
Optical (fluorimetry) test based on reduction of NAD+ to NADHSelectivity given by enzyme D-lactate dehydrogenase[99]
GC MSD- and L-lactic acid derivatization by L-menthol[100]
Ultraperformance liquid chromatography-MSD- and L-lactic acid derivatization by (S)(+)-1-(2-pyrrolidinylmethyl)-pyrrolidine[101]
HPLC-MSSelectivity of a chiral column[102]