Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Figure 4

Serum OPN could predict the mortality of IPF patients. (a, b) The areas under the ROC curves of OPN and KL-6 were statistically significant in differentiating the decedent from the survivor (, cutoff value 3.24 ng/ml; , cutoff value 916 U/ml, respectively). (c) Patients with serum OPN levels above 3.24 ng/ml had a shorter survival than those with OPN levels below that (). (d) Patients with serum KL-6 levels above 916 U/ml had a higher mortality than those below 916 U/ml (). (e) Kaplan–Meier analyses showed mortality was significantly higher in patients with AE-IPF than in those with S-IPF by the log-rank test ().

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