Prognostic Value of Serum Osteopontin in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Table 3

Ability of OPN to predict mortality in patients with idiopathic pulmonary fibrosis when evaluated by Cox regression.

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Age	1.055	1.007–1.105	0.025	1.055	1.007–1.015	0.024
Male	2.766	0.953–8.032	0.061
Smoker	0.847	0.398–1.801	0.066
FVC%	0.961	0.923–1.001	0.057
DLCO%	0.965	0.926–1.006	0.092
CRP	1.012	1.006–1.019	<0.001	1.013	1.013–1.019	<0.001
LDH	1.009	1.006–1.012	<0.001	1.009	1.006–1.013	<0.001
OPN (continuous)	1.100	1.006–1.202	0.036	1.010	1.001–1.019	0.032
KL-6 (continuous)	1.000	1.000–1.000	0.007	1.000	1.000–1.000	0.007

, , . The data are shown as the HR with the 95% CI. HR, hazard ratio; CI, confidence interval.