A Pipeline to Call Multilevel Expression Changes between Cancer and Normal Tissues and Its Applications in Repurposing Drugs Effective for Gastric Cancer

Figure 8

Drug screening process. (a) Expression spectrum data obtained from drug disturbance experiment; (b) cancer analysis sample data, including experiment and control group; (c) gene expression difference analysis of data in (b) to obtain gene set with significant difference expression. (d) Match the difference gene corresponding to different drugs in (a) with the gastric cancer difference gene obtained in (c) (because it is to use drugs for correction treatment, the down-regulated gene caused by drugs will match the up-regulated gene caused by gastric cancer, and the up-regulated gene caused by drugs will match the down-regulated gene caused by gastric cancer) and (e) set the corresponding threshold standard. Select the drug with high matching degree as the candidate treatment drug.