Optimization of Ultrasound-Assisted Extraction of Flavonoids from Celastrus hindsii Leaves Using Response Surface Methodology and Evaluation of Their Antioxidant and Antitumor Activities

Table 2

Box–Behnken design matrix in coded values and experimental results.

Run	Variable				Response, Y
	X1	X2	X3	X4
1	1	–1	0	0	20.55 ± 1.13
2	1	0	–1	0	19.44 ± 1.13
3	1	0	0	–1	21.41 ± 1.01
4	1	0	0	1	20.70 ± 0.87
5	–1	0	0	–1	23.13 ± 1.27
6	0	–1	–1	0	19.44 ± 0.28
7	0	0	1	1	19.87 ± 0.21
8	–1	0	–1	0	21.13 ± 1.01
9	–1	1	0	0	21.41 ± 1.36
10	0	1	1	0	17.80 ± 0.63
11	0	1	–1	0	21.23 ± 0.87
12	0	–1	0	–1	21.59 ± 1.76
13	0	0	–1	1	20.20 ± 0.65
14	0	0	1	–1	19.80 ± 0.38
15	–1	0	0	1	21.63 ± 0.53
16	–1	0	1	0	20.88 ± 0.45
17	1	0	1	0	19.16 ± 0.48
18	0	1	0	1	19.84 ± 0.70
19	1	1	0	0	18.87 ± 1.04
20	–1	–1	0	0	21.48 ± 0.84
21	0	–1	1	0	20.66 ± 0.65
22	0	–1	0	1	21.05 ± 1.16
23	0	0	–1	–1	20.62 ± 0.77
24	0	1	0	–1	21.37 ± 1.34
25	0	0	0	0	23.56 ± 1.49
26	0	0	0	0	23.52 ± 1.41
27	0	0	0	0	23.49 ± 1.56