Exosomal MicroRNAs in Serum as Potential Biomarkers for Ectopic Pregnancy

Table 2

Diagnostic value of the single marker and multimarker panels to predict EP or SA or VIP in early symptomatic pregnancies.

Characteristic	EP			SA			VIP
	AUC (95% CI)	Sen.	Spe.	AUC (95% CI)	Sen.	Spe.	AUC (95% CI)	Sen.	Spe.
Progesterone	0.79 (0.59-0.99)	0.73	0.92	0.41 (0.18-0.64)	0.56	0.52	0.68 (0.50-0.86)	0.99	0.40
hCG	0.67 (0.48-0.86)	0.73	0.72	0.69 (0.50-0.88)	0.89	0.63	0.49 (0.29-0.70)	0.13	0.99
miR-100-5P	0.39 (0.20-0.58)	0.55	0.52	0.69 (0.45-0.93)	0.78	0.70	0.74 (0.57-0.90)	0.81	0.60
miR-122-5P	0.67 (0.47-0.87)	0.91	0.44	0.62 (0.40-0.85)	0.67	0.63	0.74 (0.57-0.91)	0.81	0.65
miR-146a-5P	0.73 (0.57-0.90)	0.91	0.56	0.57 (0.35-0.79)	0.56	0.70	0.75 (0.58-0.93)	0.75	0.75
miR-184	0.58 (0.38-0.78)	0.91	0.48	0.73 (0.51-0.95)	0.78	0.74	0.74 (0.57-0.92)	0.63	0.85
miR-215-5P	0.73 (0.56-0.91)	0.91	0.60	0.44 (0.21-0.66)	0.67	0.41	0.75 (0.58-0.92)	0.69	0.85
miR-378d	0.72 (0.52-0.91)	0.91	0.64	0.54 (0.34-0.74)	0.89	0.44	0.72 (0.52-0.91)	0.75	0.85
hCG+P	0.81 (0.63-0.99)	0.73	0.88	0.63 (0.39-0.86)	0.56	0.78	0.67 (0.48-0.85)	0.88	0.55
hCG+P+miR-100-5P	0.87 (0.74-0.99)	0.73	0.96	0.69 (0.50-0.88)	0.89	0.52	0.79 (0.64-0.94)	0.88	0.65
hCG+P+miR-122-5P	0.82 (0.64-0.99)	0.73	0.92	0.68 (0.48-0.88)	0.89	0.48	0.70 (0.52-0.88)	0.94	0.45
hCG+P+miR-146a-5P	0.88 (0.75-0.99)	0.91	0.76	0.64 (0.41-0.87)	0.75	0.56	0.78 (0.62-0.94)	0.88	0.70
hCG+P+miR-184	0.82 (0.64-0.99)	0.73	0.92	0.67 (0.47-0.88)	0.89	0.52	0.68 (0.50-0.86)	0.81	0.65
hCG+P+miR-215-5P	0.88 (0.74-0.99)	0.73	0.96	0.68 (0.48-0.88)	0.89	0.52	0.78 (0.62-0.93)	0.94	0.55
hCG+P+miR-378d	0.82 (0.64-0.99)	0.73	0.88	0.64 (0.42-0.86)	0.56	0.81	0.69 (0.51-0.87)	0.81	0.65
ALL	0.89 (0.79-0.99)	0.91	0.80	0.69 (0.5-0.88)	0.78	0.59	0.82 (0.69-0.96)	0.99	0.60

Sen: sensitivity; Spe: specificity; P: progesterone; ALL = hCG+progesterone+miR-100-5P+miR-122-5P+miR-146a-5P+miR-184+miR-215-5P+miR-378d.