Evaluation of the Cardiac Protection Conferred by Proanthocyanidins in Grape Seeds against Development of Ehrlich Solid Tumors in Mice

Figure 3

Photomicrographs of haematoxylin- and eosin-stained heart sections from mice in different groups. (a, b) Normal myofibrillar structure with striations shown by heart sections from mice in the control and GSPE groups. (c, d) Significant myocardial hypertrophy (arrow heads), nuclear pyknosis, focal haemorrhage, marked cytoplasmic vacuoles, and leukocyte infiltration (arrows) exhibited by heart sections from mice in the EST group. (e) Mild tissue damage with mild myocardial hypertrophy (arrow heads) and nuclear pyknosis (arrows) exhibited by heart sections from mice in the GSPE + EST group. (f) Mild myocardial hypertrophy (arrow heads), mild cytoplasmic vacuoles, and mild leukocyte infiltration (arrows) displayed by the heart sections from mice in the EST + GSPE group.

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