Deterioration of Health-Related Quality of Life Scores under Treatment Predicts Longer Survival

Table 4

Univariate and multivariate analyses according to Cox’s proportional hazards model for sociodemographic and clinical variables and HRQoL change scores.

	Univariate analysis			Multivariate analysis
	Hazard ratio	95% C.I.		Hazard ratio	95% C.I.
T category (T1/T2 (] vs. T3/T4 ())	1.144	0.629–2.081	0.660	—	—	—
N category (N0 () vs. N+ ())	1.290	0.694–2.397	0.421	—	—	—
M category (M0 () vs. M+ ())	1.745	0.956–3.187	0.070	1.895	1.069–3.359	0.029
Gender (male () vs. female ())	1.068	0.607–1.879	0.820	—	—	—
Age (<60 years (] vs. >60 years ())	1.954	1.095–3.454	0.023	2.113	1.209–3.695	0.009
Physical functioning (above () vs. below median (n = 124))	1.742	0.904–3.355	0.097	1.487	0.832–2.657	0.180
Role functioning (below () vs. above median ())	0.712	0.391–1.297	0.267	0.61	0.359–1.039	0.069
Global health status (above () vs. below median ())	0.555	0.298–1.034	0.064	—	—	—
Fatigue (above () vs. below median ())	0.927	0.489–1.757	0.816	—	—	—
Pain (below (n) vs. above median ())	0.356	0.184–0.688	0.002	0.36	0.193–0.67	0.001
Appetite loss (below () vs. above median ())	0.783	0.431–1.424	0.423	—	—	—