Review Article
Clinical Significance of PIK3CA Gene in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis
Table 2
Associations of PIK3CA mutation with clinicopathological characteristics in non-small-cell lung cancer.
| | Author | Sex (M vs. F) | Age (≥60 vs. <60) | Lymph node metastasis (+ vs. -) | TNM (advanced vs. limited) | Smoking history (yes vs. no) |
| | Ludovini [17] | 0.406 (0.077-2.148) | | | | 0.709 (0.148-3.384) | | Zhang [18] | | 0.691 (0.333-1.434) | 2.823 (1.128-7.065) | 2.083 (0.890-4.877) | 1.109 (0.532-2.314) | | Wang [21] | — | — | — | — | — | | Vieira [22] | — | — | — | — | — | | McGowan [23] | 1.080 (0.551-2.118) | | | 0.974 (0.399-2.378) | — | | Song [24] | 1.341 (0.587-3.063) | 1.473 (0.654-3.321) | | 0.962 (0.427-2.167) | | | Imperatori [25] | — | — | — | — | — | | Wang [26] | — | — | — | — | — | | Chang [27] | — | — | — | — | — | | Aredo [28] | — | — | — | — | — | | Overall ( (95% CI), ; , ) | 1.07 (0.65-1.76), 0.789; 0.0, 0.452 | 0.97 (0.56-1.67), 0.910; 45.8, 0.174 | — | 1.25 (0.76-2.04), 0.375; 4.0, 0.353 | 1.02 (0.53-1.99), 0.947; 0.0, 0.612 |
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RR: relative risk; CI: confidence interval; M: male; F: female; TNM: tumor-node-metastasis.
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